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Ionis Pharmaceuticals, Inc. (IONS)

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Ionis Pharmaceuticals faces severe near-term volatility following a Phase 3 ATTR cardiomyopathy trial miss with AstraZeneca, yet retains robust underlying fundamentals, highlighted by strong early sales momentum for TRYNGOLZA and $1.9B to $2.1B in liquidity supporting its 2028 breakeven path.

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